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A Graph Search-Empowered Integrative Database of Arabidopsis Signaling Transduction, Metabolism and Gene Regulation Networks   
Location:  Home > Details for node EDS1
Type: Protein GRN ID: np08017 Name: EDS1
Annotation: EDS1, ATEDS1 | alpha/beta-Hydrolases superfamily protein
Gene Locus: AT3G48090
References:
  • Falk A, Feys BJ, Frost LN, Jones JD, Daniels MJ, Parker JE. EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3292-7. PubMed PMID: 10077677; PubMed Central PMCID: PMC15935.
  • Parker JE, Holub EB, Frost LN, Falk A, Gunn ND, Daniels MJ. Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes. Plant Cell. 1996 Nov;8(11):2033-46. PubMed PMID: 8953768; PubMed Central PMCID: PMC161332.
  • Aarts N, Metz M, Holub E, Staskawicz BJ, Daniels MJ, Parker JE. Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10306-11. PubMed PMID: 9707643; PubMed Central PMCID: PMC21504.
 
Pathways: Salicylic acid;  Ethylene 
Gene Expression (Affy ATH1 probeset): 252373_at    
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 Protein modification
 Protein-protein interaction
        also include predicted relationship
 Compound-protein interaction
 TF-target gene regulation
 Small RNA-target regulation
        also include predicted relationship
 Carrier and transported molecule
 Catalytic chemical reaction
 Co-expressed gene pair
        with mutual information value >

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Relationship type:  protein modification     catalytic chemical reaction     protein-protein interaction    
compound-protein interaction     TF-target gene regulation     small RNA-target regulation    
co-expressed gene pair     carrier and transported molecule     family/complex and member
Relationship evidence:  Solid line: validated          Dashed line: predicted
Relationship direction: Arrow: positive          T shape: negative          None arrow: unknown or n/a
Hormone association: Thicker line: hormone related relationship         : hormone related Node
Node type:  Transcription factor or transcriptional regulator       Compound       Kinase
 Small regulatory RNA (miRNA & ta-siRNA)       Other nodes
No. Path
2 EDS1  --  has product (in catalytic reaction)  --  SA
3 EDS1  --  interacts with  --  FAB2; SSI2
4 EDS1  --  interacts with  --  PAD4
5 EDS1  --  interacts with  --  BAL; SNC1
6 EDS1  --  interacts with  --  RPS6; RPS6A
7 EDS1  --  interacts with  --  RPS4
8 EDS1  --  interacts with  --  SRFR1
9 EDS1  --  interacts with  --  LSU1
10 EDS1  --  interacts with  --  SAG101
11 EDS1  --  is a member of  --  EDS1 family115, coding gene
12 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY7; WRKY7
13 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY11; WRKY11
14 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY17; WRKY17
15 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATGSTF5; ATGSTF8; GST6; GSTF8
16 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATRAD51D
17 EDS1  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  PTAC/ATUHY1/ATWHY1
18 EDS1  --  has product (in catalytic reaction)  --  SA  --  interacts with  --  unknown receptor
19 EDS1  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  prephenic acid
20 EDS1  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  Gentisic acid
21 EDS1  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  MeSA
22 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  ATWRKY52; RRS1; SLH1
23 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  BON; BON1; CPN1
24 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  ATGSL05; ATGSL5; GSL05; GSL05; GSL5; PMR4
25 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  CPR22
26 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  lsd6
27 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  Benzoic Acid
28 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  AtMES1 family113, coding gene
29 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  O-coumarate
30 EDS1  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  Isochorismate
31 EDS1  --  interacts with  --  FAB2; SSI2  --  interacts with  --  PDF1.2;LCR77
32 EDS1  --  interacts with  --  FAB2; SSI2  --  interacts with  --  AT5G62890
33 EDS1  --  interacts with  --  FAB2; SSI2  --  interacts with  --  AT5G14020
34 EDS1  --  interacts with  --  FAB2; SSI2  --  interacts with  --  BR6OX2
35 EDS1  --  interacts with  --  FAB2; SSI2  --  has product (in catalytic reaction)  --  Acceptor
36 EDS1  --  interacts with  --  FAB2; SSI2  --  has product (in catalytic reaction)  --  Oleoyl-[acyl-carrier protein]
37 EDS1  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.812951) with  --  NAGK
38 EDS1  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.814561) with  --  DiT1
39 EDS1  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.816756) with  --  ASN2
40 EDS1  --  interacts with  --  PAD4  --  interacts with  --  PR1
41 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  PR2
42 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  ATIMPALPHA3; IMPA-3; MOS6
43 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  EMB2789; MOS7
44 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  MOS3; NUP96; PRE; SAR3
45 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  ATUBA1; MOS5; UBA1
46 EDS1  --  interacts with  --  BAL; SNC1  --  interacts with  --  MOS2
47 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.970219) with  --  AT2G29360
48 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.860776) with  --  ATGSTU18; GST29; GSTU18
49 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.919513) with  --  PSAH-1
50 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.927396) with  --  AT3G26080
51 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.927396) with  --  AT3G26070
52 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.928251) with  --  AT3G19800
53 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.877186) with  --  AT1G69550
54 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.923421) with  --  AT1G51805
55 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.877071) with  --  PGR5-LIKE A
56 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.955049) with  --  RPP13
57 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.904328) with  --  AT3G47070
58 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.964117) with  --  CP12; CP12-2
59 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.9596) with  --  GSTL3
60 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.882456) with  --  anac084; NAC084
61 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.932293) with  --  AT5G38980
62 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=1.01386) with  --  AT5G40500
63 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.808431) with  --  AT5G43440
64 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.892602) with  --  ATLFNR1; FNR1
65 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.915223) with  --  FTRA2
66 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.993187) with  --  AT1G33600
67 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=1.14472) with  --  RPP5
68 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.930751) with  --  AT1G59124
69 EDS1  --  interacts with  --  BAL; SNC1  --  has similar expression pattern (mutual information value=0.930751) with  --  AT1G58807
70 EDS1  --  interacts with  --  RPS6; RPS6A  --  interacts with  --  AHL29; SOB3
71 EDS1  --  interacts with  --  RPS6; RPS6A  --  interacts with  --  AtMC9; AtMCP2f; MC9; MCP2f
72 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.04397) with  --  RPL24A
73 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=0.814274) with  --  ATRNR1; CLS8; R1; RNR1
74 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.30658) with  --  RPL10; RPL10A; SAC52
75 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.08671) with  --  AT3G12860
76 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=0.986082) with  --  AT3G23940
77 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.22731) with  --  ATHD2A; HD2A; HDA3; HDT1
78 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=0.957425) with  --  ATEIF3E-1; ATINT6; EIF3E; INT-6; INT6; TIF3E1
79 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.35406) with  --  AT5G02870
80 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.04619) with  --  ATEBP1; ATG2; EBP1
81 EDS1  --  interacts with  --  RPS6; RPS6A  --  has similar expression pattern (mutual information value=1.08981) with  --  AT4G16720
82 EDS1  --  interacts with  --  RPS6; RPS6A  --  is modified by  --  ATPK19; ATPK2; ATS6K2; S6K2
83 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AT1G35560
84 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AT1G72010
85 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AT-TCP20; ATTCP20; PCF1; TCP20
86 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AtTCP15; TCP15
87 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  TCP8
88 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AtSGT1B
89 EDS1  --  interacts with  --  SRFR1  --  interacts with  --  AtSGT1A
90 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ATSPX4; SPX4
91 EDS1  --  interacts with  --  LSU1  --  interacts with  --  RPS18C
92 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G18630
93 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G57910
94 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G22890
95 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G09770
96 EDS1  --  interacts with  --  LSU1  --  interacts with  --  VAR3
97 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G23130
98 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ASHR3; SDG4
99 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G26310
100 EDS1  --  interacts with  --  LSU1  --  interacts with  --  PSAD-1
101 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ATPTEN1; PTEN1
102 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AtCIB22; CIB22
103 EDS1  --  interacts with  --  LSU1  --  interacts with  --  VPS9B
104 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G66720
105 EDS1  --  interacts with  --  LSU1  --  interacts with  --  PBF1
106 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ful
107 EDS1  --  interacts with  --  LSU1  --  interacts with  --  FSD2
108 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G65220
109 EDS1  --  interacts with  --  LSU1  --  interacts with  --  HMA6; PAA1
110 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G28200
111 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G54580
112 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G36970
113 EDS1  --  interacts with  --  LSU1  --  interacts with  --  TOE2
114 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G11090
115 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G65683
116 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G30490
117 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G12450
118 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT5G38420
119 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT4G39820
120 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AtPP2-B5; PP2-B5
121 EDS1  --  interacts with  --  LSU1  --  interacts with  --  LSH4
122 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G01440
123 EDS1  --  interacts with  --  LSU1  --  interacts with  --  NRPB6B; NRPE6B
124 EDS1  --  interacts with  --  LSU1  --  interacts with  --  BLH8; PNF
125 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G32840
126 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G11430
127 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ATGRX2; CXIP2
128 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G38300
129 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G06790
130 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G16930
131 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G13160
132 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G08740
133 EDS1  --  interacts with  --  LSU1  --  interacts with  --  NF-YA4
134 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G32580
135 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G06270
136 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G06590
137 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G28900
138 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G04390
139 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ATERF12
140 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G77400
141 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G17880
142 EDS1  --  interacts with  --  LSU1  --  interacts with  --  SKL2
143 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G24860
144 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G35240
145 EDS1  --  interacts with  --  LSU1  --  interacts with  --  GATA24; TIFY2B; ZML1; ZML1
146 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G43370
147 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G53800
148 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G26740
149 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G71970
150 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G03250
151 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT2G26800
152 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G34030
153 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ZFP7
154 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ATCFM2; CFM2
155 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G75400
156 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G31050
157 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT1G49850
158 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G13310
159 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G05625
160 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AtSS2; SS2
161 EDS1  --  interacts with  --  LSU1  --  interacts with  --  JAZ9
162 EDS1  --  interacts with  --  LSU1  --  interacts with  --  AT3G07480
163 EDS1  --  interacts with  --  LSU1  --  interacts with  --  ENA
164 EDS1  --  interacts with  --  LSU1  --  interacts with  --  JAZ1
165 EDS1  --  interacts with  --  LSU1  --  interacts with  --  PAB3
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