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A Graph Search-Empowered Integrative Database of Arabidopsis Signaling Transduction, Metabolism and Gene Regulation Networks   
Location:  Home > Details for node PAD4
Type: Protein GRN ID: np08019 Name: PAD4
Annotation: PAD4, ATPAD4 | alpha/beta-Hydrolases superfamily protein
Gene Locus: AT3G52430
References:
  • Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE, Ausubel FM, Glazebrook J. Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13583-8. PubMed PMID: 10557364; PubMed Central PMCID: PMC23991.
  • Glazebrook J, Zook M, Mert F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM. Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance. Genetics. 1997 May;146(1):381-92. PubMed PMID: 9136026; PubMed Central PMCID: PMC1207952.
  • Glazebrook J, Rogers EE, Ausubel FM. Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening. Genetics. 1996 Jun;143(2):973-82. PubMed PMID: 8725243; PubMed Central PMCID: PMC1207353.
  • Zhou N, Tootle TL, Tsui F, Klessig DF, Glazebrook J. PAD4 functions upstream from salicylic acid to control defense responses in Arabidopsis. Plant Cell. 1998 Jun;10(6):1021-30. PubMed PMID: 9634589; PubMed Central PMCID: PMC144042.
 
Pathways: Salicylic acid;  Ethylene;  Jasmonates 
Gene Expression (Affy ATH1 probeset): 252060_at    
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 Protein modification
 Protein-protein interaction
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 Compound-protein interaction
 TF-target gene regulation
 Small RNA-target regulation
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 Carrier and transported molecule
 Catalytic chemical reaction
 Co-expressed gene pair
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Relationship type:  protein modification     catalytic chemical reaction     protein-protein interaction    
compound-protein interaction     TF-target gene regulation     small RNA-target regulation    
co-expressed gene pair     carrier and transported molecule     family/complex and member
Relationship evidence:  Solid line: validated          Dashed line: predicted
Relationship direction: Arrow: positive          T shape: negative          None arrow: unknown or n/a
Hormone association: Thicker line: hormone related relationship         : hormone related Node
Node type:  Transcription factor or transcriptional regulator       Compound       Kinase
 Small regulatory RNA (miRNA & ta-siRNA)       Other nodes
No. Path
2 PAD4  --  has product (in catalytic reaction)  --  SA
3 PAD4  --  interacts with  --  PR1
4 PAD4  --  interacts with  --  FAB2; SSI2
5 PAD4  --  interacts with  --  SAG101
6 PAD4  --  interacts with  --  EDS1
7 PAD4  --  interacts with  --  AT3G48080
8 PAD4  --  is a member of  --  EDS1 family115, coding gene
9 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY7; WRKY7
10 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY11; WRKY11
11 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATWRKY17; WRKY17
12 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATGSTF5; ATGSTF8; GST6; GSTF8
13 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  ATRAD51D
14 PAD4  --  has product (in catalytic reaction)  --  SA  --  regulates the expression of   --  PTAC/ATUHY1/ATWHY1
15 PAD4  --  has product (in catalytic reaction)  --  SA  --  interacts with  --  unknown receptor
16 PAD4  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  prephenic acid
17 PAD4  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  Gentisic acid
18 PAD4  --  has product (in catalytic reaction)  --  SA  --  has product (in catalytic reaction)  --  MeSA
19 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  ATWRKY52; RRS1; SLH1
20 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  BON; BON1; CPN1
21 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  ATGSL05; ATGSL5; GSL05; GSL05; GSL5; PMR4
22 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  CPR22
23 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  lsd6
24 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  Benzoic Acid
25 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  AtMES1 family113, coding gene
26 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  O-coumarate
27 PAD4  --  has product (in catalytic reaction)  --  SA  --  is product (in catalytic reaction) of  --  Isochorismate
28 PAD4  --  interacts with  --  PR1  --  interacts with  --  MKK7
29 PAD4  --  interacts with  --  PR1  --  interacts with  --  GRX480; roxy19
30 PAD4  --  interacts with  --  PR1  --  interacts with  --  ATSIZ1
31 PAD4  --  interacts with  --  PR1  --  interacts with  --  SSI4
32 PAD4  --  interacts with  --  PR1  --  interacts with  --  SNI1
33 PAD4  --  interacts with  --  PR1  --  interacts with  --  DTH9
34 PAD4  --  interacts with  --  PR1  --  transport  --  Fe3+
35 PAD4  --  interacts with  --  PR1  --  transport  --  Aluminium
36 PAD4  --  interacts with  --  PR1  --  transport  --  DL-Glycerol 1-phosphate
37 PAD4  --  interacts with  --  PR1  --  transport  --  Ornithine
38 PAD4  --  interacts with  --  PR1  --  transport  --  Mannitol
39 PAD4  --  interacts with  --  PR1  --  transport  --  Thiamine
40 PAD4  --  interacts with  --  PR1  --  transport  --  Lactose
41 PAD4  --  interacts with  --  PR1  --  transport  --  Maltose
42 PAD4  --  interacts with  --  PR1  --  transport  --  Sucrose
43 PAD4  --  interacts with  --  PR1  --  transport  --  Iron
44 PAD4  --  interacts with  --  PR1  --  is a member of  --  PR1 family109, coding gene
45 PAD4  --  interacts with  --  PR1  --  is regulated by  --  ARR2 complex18
46 PAD4  --  interacts with  --  PR1  --  is regulated by  --  OBF4
47 PAD4  --  interacts with  --  PR1  --  is regulated by  --  TGA1
48 PAD4  --  interacts with  --  PR1  --  is regulated by  --  BZIP45
49 PAD4  --  interacts with  --  PR1  --  is regulated by  --  OBF5
50 PAD4  --  interacts with  --  PR1  --  is regulated by  --  AHBP-1B
51 PAD4  --  interacts with  --  PR1  --  is regulated by  --  TGA3
52 PAD4  --  interacts with  --  PR1  --  has similar expression pattern (mutual information value=0.893456) with  --  CRK6
53 PAD4  --  interacts with  --  PR1  --  has similar expression pattern (mutual information value=0.893456) with  --  CRK8
54 PAD4  --  interacts with  --  PR1  --  has similar expression pattern (mutual information value=0.831662) with  --  AT5G10760
55 PAD4  --  interacts with  --  FAB2; SSI2  --  interacts with  --  PDF1.2;LCR77
56 PAD4  --  interacts with  --  FAB2; SSI2  --  interacts with  --  AT5G62890
57 PAD4  --  interacts with  --  FAB2; SSI2  --  interacts with  --  AT5G14020
58 PAD4  --  interacts with  --  FAB2; SSI2  --  interacts with  --  BR6OX2
59 PAD4  --  interacts with  --  FAB2; SSI2  --  has product (in catalytic reaction)  --  Acceptor
60 PAD4  --  interacts with  --  FAB2; SSI2  --  has product (in catalytic reaction)  --  Oleoyl-[acyl-carrier protein]
61 PAD4  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.812951) with  --  NAGK
62 PAD4  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.814561) with  --  DiT1
63 PAD4  --  interacts with  --  FAB2; SSI2  --  has similar expression pattern (mutual information value=0.816756) with  --  ASN2
64 PAD4  --  interacts with  --  EDS1  --  interacts with  --  BAL; SNC1
65 PAD4  --  interacts with  --  EDS1  --  interacts with  --  RPS6; RPS6A
66 PAD4  --  interacts with  --  EDS1  --  interacts with  --  RPS4
67 PAD4  --  interacts with  --  EDS1  --  interacts with  --  SRFR1
68 PAD4  --  interacts with  --  EDS1  --  interacts with  --  LSU1
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