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Location:  Home > Details for node TIR1
Type: Protein GRN ID: np02055 Name: TIR1
Annotation: TIR1 | F-box/RNI-like superfamily protein [TCDB:3.A.18.1]
Gene Locus: AT3G62980
References:
  • Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N. Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature. 2007 Apr 5;446(7136):640-5. PubMed PMID: 17410169.
  • Gray WM, Muskett PR, Chuang HW, Parker JE. Arabidopsis SGT1b is required for SCF(TIR1)-mediated auxin response. Plant Cell. 2003 Jun;15(6):1310-9. PubMed PMID: 12782725; PubMed Central PMCID: PMC156368.
  • Gray WM, del Pozo JC, Walker L, Hobbie L, Risseeuw E, Banks T, Crosby WL, Yang M, Ma H, Estelle M. Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes Dev. 1999 Jul 1;13(13):1678-91. PubMed PMID: 10398681; PubMed Central PMCID: PMC316846.
  • Chuang HW, Zhang W, Gray WM. Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase. Plant Cell. 2004 Jul;16(7):1883-97. Epub 2004 Jun 18. PubMed PMID: 15208392; PubMed Central PMCID: PMC514168.
 
Pathways: Auxins;  Gibberellins 
Gene Expression (Affy ATH1 probeset): 251199_at    
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Data Filter
 Protein modification
 Protein-protein interaction
        also include predicted relationship
 Compound-protein interaction
 TF-target gene regulation
 Small RNA-target regulation
        also include predicted relationship
 Carrier and transported molecule
 Catalytic chemical reaction
 Co-expressed gene pair
        with mutual information value >

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Relationship type:  protein modification     catalytic chemical reaction     protein-protein interaction    
compound-protein interaction     TF-target gene regulation     small RNA-target regulation    
co-expressed gene pair     carrier and transported molecule     family/complex and member
Relationship evidence:  Solid line: validated          Dashed line: predicted
Relationship direction: Arrow: positive          T shape: negative          None arrow: unknown or n/a
Hormone association: Thicker line: hormone related relationship         : hormone related Node
Node type:  Transcription factor or transcriptional regulator       Compound       Kinase
 Small regulatory RNA (miRNA & ta-siRNA)       Other nodes
No. Path
2 TIR1  --  interacts with  --  AFB1
3 TIR1  --  interacts with  --  AFB5
4 TIR1  --  interacts with  --  AXR5
5 TIR1  --  interacts with  --  AUX1
6 TIR1  --  interacts with  --  AXR3
7 TIR1  --  interacts with  --  IAA28
8 TIR1  --  interacts with  --  IAA8
9 TIR1  --  interacts with  --  ATAUX2-27; AUX2-27; IAA5
10 TIR1  --  interacts with  --  IAA3
11 TIR1  --  interacts with  --  AXR2
12 TIR1  --  interacts with  --  CIP1
13 TIR1  --  interacts with  --  AFB3
14 TIR1  --  interacts with  --  ASK3; SK3
15 TIR1  --  interacts with  --  BDL
16 TIR1  --  interacts with  --  ASK9; SK9
17 TIR1  --  interacts with  --  RCE1
18 TIR1  --  interacts with  --  IAA14
19 TIR1  --  is the target gene of  --  ath-miR852
20 TIR1  --  is the target gene of  --  ath-miR393b
21 TIR1  --  is the target gene of  --  ath-miR393a
22 TIR1  --  is a member of  --  TIR1 family31, coding gene
23 TIR1  --  interacts with  --  AFB1  --  interacts with  --  IAA29
24 TIR1  --  interacts with  --  AFB1  --  interacts with  --  AFB2
25 TIR1  --  interacts with  --  AFB1  --  interacts with  --  BOI; RING
26 TIR1  --  interacts with  --  AFB1  --  interacts with  --  AT2G42390
27 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.918808) with  --  BGAL5
28 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.869815) with  --  AT3G12710
29 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.900916) with  --  YUUCA8
30 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.808083) with  --  ATBZIP61; BZIP61
31 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.812724) with  --  GASA4
32 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.88412) with  --  ATHB-3; ATHB3; HAT7; HB-3
33 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=1.29978) with  --  LNG1
34 TIR1  --  interacts with  --  AFB1  --  has similar expression pattern (mutual information value=0.958377) with  --  AT5G19340
35 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF14
36 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF2/ARF1-BP
37 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF11
38 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF13
39 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF10
40 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF7
41 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF6
42 TIR1  --  interacts with  --  AXR5  --  regulates the expression of   --  ARF4
43 TIR1  --  interacts with  --  AXR5  --  interacts with  --  ARF17
44 TIR1  --  interacts with  --  AXR5  --  interacts with  --  ARF9
45 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA16
46 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA19
47 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA31
48 TIR1  --  interacts with  --  AXR5  --  interacts with  --  ATAUX2-11; IAA4
49 TIR1  --  interacts with  --  AXR5  --  interacts with  --  ARF5
50 TIR1  --  interacts with  --  AXR5  --  interacts with  --  ARF8
51 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA34
52 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA9
53 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA15
54 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA27; PAP2
55 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA30
56 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA2
57 TIR1  --  interacts with  --  AXR5  --  interacts with  --  UGT74D1
58 TIR1  --  interacts with  --  AXR5  --  interacts with  --  GLP4
59 TIR1  --  interacts with  --  AXR5  --  interacts with  --  AT3G18140
60 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA18
61 TIR1  --  interacts with  --  AXR5  --  interacts with  --  IAA6; SHY1
62 TIR1  --  interacts with  --  AXR5  --  interacts with  --  TPR3
63 TIR1  --  interacts with  --  AXR5  --  interacts with  --  TPR2
64 TIR1  --  interacts with  --  AXR5  --  interacts with  --  TPR1
65 TIR1  --  interacts with  --  AXR5  --  is a member of  --  family38, transcription factor interactor and regulator gene
66 TIR1  --  interacts with  --  AXR5  --  is a member of  --  IAA3 family34, transcription factor interactor and regulator gene
67 TIR1  --  interacts with  --  AXR5  --  is modified by  --  MPK16
68 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT5G03345
69 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT1G16170
70 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT4; ATIPS2
71 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT3G03210
72 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT5G11680
73 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT3G62560
74 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT4G12590
75 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT3G26370
76 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT1G14020
77 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT4G01410
78 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AT5G25940
79 TIR1  --  interacts with  --  AUX1  --  interacts with  --  ABCI12
80 TIR1  --  interacts with  --  AUX1  --  interacts with  --  AGP27; ATAGP27
81 TIR1  --  interacts with  --  AUX1  --  interacts with  --  ATFACE-2; ATFACE2; FACE2; RCE1
82 TIR1  --  interacts with  --  AUX1  --  interacts with  --  LRR1
83 TIR1  --  interacts with  --  AUX1  --  interacts with  --  DAD2
84 TIR1  --  interacts with  --  AUX1  --  interacts with  --  ATPLC2; PLC2
85 TIR1  --  interacts with  --  AUX1  --  is a member of  --  AUX1 family30, coding gene
86 TIR1  --  interacts with  --  AXR3  --  interacts with  --  IAA26; PAP1
87 TIR1  --  interacts with  --  AXR3  --  interacts with  --  ARF1
88 TIR1  --  interacts with  --  AXR3  --  interacts with  --  IAA20
89 TIR1  --  interacts with  --  AXR3  --  interacts with  --  IAA13
90 TIR1  --  interacts with  --  AXR3  --  interacts with  --  IAA10
91 TIR1  --  interacts with  --  AXR3  --  interacts with  --  ARF20
92 TIR1  --  interacts with  --  AXR3  --  interacts with  --  ARF18
93 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=1.14712) with  --  ACLA-2
94 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=0.905943) with  --  AT1G65010
95 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=0.857614) with  --  CAT1
96 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=0.953225) with  --  AT3G18200
97 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=0.817793) with  --  AT3G57810
98 TIR1  --  interacts with  --  AXR3  --  has similar expression pattern (mutual information value=1.00628) with  --  AT5G39320
99 TIR1  --  interacts with  --  IAA28  --  regulates the expression of   --  ARF12
100 TIR1  --  interacts with  --  IAA28  --  regulates the expression of   --  ARF1; ATARF; ATARF1; ATARFA1A
101 TIR1  --  interacts with  --  IAA28  --  interacts with  --  IAA33
102 TIR1  --  interacts with  --  IAA28  --  interacts with  --  IAA11
103 TIR1  --  interacts with  --  IAA28  --  interacts with  --  ARF22
104 TIR1  --  interacts with  --  IAA8  --  regulates the expression of   --  ARF16
105 TIR1  --  interacts with  --  IAA8  --  regulates the expression of   --  AtTPR2; TPR2
106 TIR1  --  interacts with  --  IAA8  --  interacts with  --  ARF15
107 TIR1  --  interacts with  --  IAA8  --  interacts with  --  AtHB32; HB32; ZHD14
108 TIR1  --  interacts with  --  ATAUX2-27; AUX2-27; IAA5  --  interacts with  --  IAA32; MEE10
109 TIR1  --  interacts with  --  IAA3  --  regulates the expression of   --  ATIPT5
110 TIR1  --  interacts with  --  IAA3  --  regulates the expression of   --  ATPIN1 family27, coding gene
111 TIR1  --  interacts with  --  IAA3  --  regulates the expression of   --  ATIPT1 family54, coding gene
112 TIR1  --  interacts with  --  IAA3  --  regulates the expression of   --  ASL18; LBD16
113 TIR1  --  interacts with  --  IAA3  --  is regulated by  --  ARR12
114 TIR1  --  interacts with  --  IAA3  --  is regulated by  --  ARR1
115 TIR1  --  interacts with  --  IAA3  --  interacts with  --  ATGRX2; CXIP2
116 TIR1  --  interacts with  --  IAA3  --  interacts with  --  ATGRX4; GRX4
117 TIR1  --  interacts with  --  IAA3  --  interacts with  --  AT1G09500
118 TIR1  --  interacts with  --  IAA3  --  interacts with  --  Phytochrome B (PhyB)
119 TIR1  --  interacts with  --  IAA3  --  has similar expression pattern (mutual information value=0.810977) with  --  AT4G09890
120 TIR1  --  interacts with  --  AXR2  --  interacts with  --  ATCUL1
121 TIR1  --  interacts with  --  AXR2  --  interacts with  --  TIR
122 TIR1  --  interacts with  --  AXR2  --  has similar expression pattern (mutual information value=0.888679) with  --  PKS2
123 TIR1  --  interacts with  --  AXR2  --  is regulated by  --  HY5
124 TIR1  --  interacts with  --  CIP1  --  interacts with  --  COP1
125 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  UFO
126 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G15430
127 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G58930
128 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  TGA1
129 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G03030
130 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G10400
131 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  HS; HWS
132 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  ADO3; FKF1
133 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  ADO2; LKP2
134 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G03360
135 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G67140
136 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G56420
137 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G53840
138 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G49610
139 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G45360
140 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G44980
141 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G39250
142 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT5G03970
143 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G27050
144 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G26340
145 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G18380
146 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  CPR30
147 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  FBW2
148 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G05460
149 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  EID1
150 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  DAF1
151 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G60710
152 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59250
153 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59210
154 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59200
155 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59160
156 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59150
157 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G59000
158 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  SKIP5; SKP5
159 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G48880
160 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G26010
161 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G19560
162 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT3G06240
163 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT2G29820
164 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT2G26860
165 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT2G20380
166 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT2G17030
167 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AtPP2-B1; PP2-B1
168 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G78760
169 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G70590
170 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G69630
171 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G67190
172 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G66310
173 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G57790
174 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G51550
175 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G23780
176 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G23390
177 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  ATFBP7; FBP7
178 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G13570
179 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G11270
180 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT1G60080
181 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT2G04230
182 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  AT4G02740
183 TIR1  --  interacts with  --  ASK3; SK3  --  interacts with  --  ADO1; FKL2; LKP1; ZTL
184 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.928859) with  --  ATTOM22-I; TOM22-I
185 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.891913) with  --  AT1G12830
186 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.91691) with  --  AT3G07590
187 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.825441) with  --  AT3G49890
188 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.87836) with  --  AT5G06190
189 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.813209) with  --  AT5G61880
190 TIR1  --  interacts with  --  ASK3; SK3  --  has similar expression pattern (mutual information value=0.927376) with  --  KIWI
191 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT1G27340
192 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT1G76920
193 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AtPP2-A14; PP2-A14
194 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT4G19940
195 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT3G57580
196 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT3G21130
197 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT3G16580
198 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT3G13830
199 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT1G47340
200 TIR1  --  interacts with  --  ASK9; SK9  --  interacts with  --  AT2G22030
201 TIR1  --  interacts with  --  RCE1  --  interacts with  --  ATRBX1
202 TIR1  --  interacts with  --  RCE1  --  is a member of  --  np2055 complex12
203 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  AHA11; HA11
204 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  ILL2
205 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  ILL1
206 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  AT5G10750
207 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  AT4G31830
208 TIR1  --  is the target gene of  --  ath-miR852  --  inhibit the expression of  --  AKT1
209 TIR1  --  is the target gene of  --  ath-miR393b  --  inhibit the expression of  --  AT3G23690
210 TIR1  --  is the target gene of  --  ath-miR393b  --  inhibit the expression of  --  ATWRKY33; WRKY33
211 TIR1  --  is the target gene of  --  ath-miR393b  --  is a member of  --  family36, miRNA or ta-siRNA
   Funding by the National Science Foundation    Funding by the Oklahoma Center for the Advancement of Science & Technology    Additional funding by the Samuel Roberts Noble Foundation

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