| Location: Details of bHLH family |
| |
bHLH |
| Family Type |
Transcription factor |
| Plant Specific |
No |
| Functional Domains |
DNA binding domain |
| Must-have InterProScan Domain Pattern |
IPR011598 |
| Prohibited InterProScan Domain Pattern |
- |
| Description |
bHLH is a ubiquitously present DNA binding Domain. The bHLH domain is highly conserved and comprises ~ 60 amino acids. In bHLH domains there is at least five basic amino acids in the basic region and a highly conserved His?CGlu?CArg motif, which is found in more than 50% of plant bHLHs, are predicted to bind DNA. The helix-loop-helix (HLH) region comprises two amphiphatic ?-helices, mainly consisting of hydrophobic amino acids, which are connected by a loop of variable length. Proteins containing the HLH motif often form homo- or heterodimers with other bHLH proteins, which is a prerequisite for DNA recognition and contributes to DNA-binding specificity.
Reference:
1. A. Feller, K. Machemer, E. L. Braun, E. Grotewold, Evolutionary and comparative analysis of MYB and bHLH plant transcription factors. Plant J 66, 94 (2011) |
| Cross-reference to other databases |
The family is the same family of bHLH in PlantTFDB.
The family is the same family of bHLH in PlnTFDB.
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