| Location: Details of WD40-like family |
| |
WD40-like |
| Family Type |
Transcription factor |
| Plant Specific |
No |
| Functional Domains |
Protein-protein interacting domain |
| Must-have InterProScan Domain Pattern |
IPR015943 or IPR017986 or IPR001680 or IPR019775 |
| Prohibited InterProScan Domain Pattern |
IPR000571 |
| Description |
The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions.
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). The domain folds into a beta propeller; and the domains form a platform without any catalytic activity on which multiple protein complexes assemble reversibly. WD-repeat proteins regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion.
Reference:
1. T. F. Smith, C. Gaitatzes, K. Saxena, E. J. Neer, The WD repeat: a common architecture for diverse functions. Trends Biochem Sci 24, 181 (1999) 2. T. F. Smith, Diversity of WD-repeat proteins. Subcell Biochem 48, 20 (2008).
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| Cross-reference to other databases |
The family is only defined in PlantTFcat.
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