| Location: Details of SWI-SNF family |
| |
SWI-SNF |
| Family Type |
Chromatin remodeling |
| Plant Specific |
No |
| Functional Domains |
Chromatin-remodelling complex, RSC |
| Must-have InterProScan Domain Pattern |
IPR013933 |
| Prohibited InterProScan Domain Pattern |
- |
| Description |
The Swi/Snf family of nucleosome-remodeling complexes has been shown to play important roles in gene
expression throughout eukaryotes. Genetic and biochemical studies previously suggested that Swi/Snf activates
transcription by remodeling nucleosomes, thereby permitting increased access of transcription factors for their
binding sites. Recent studies have identified additional Swi/Snf biochemical activities and have suggested
possible mechanisms by which Swi/Snf is targeted to specific promoters. Surprisingly, studies have also
revealed that, besides being necessary for activation, Swi/Snf is required for transcriptional repression of some
genes. These analyses have transformed our understanding of the function of the Swi/Snf family of complexes
and suggest that they control transcription in diverse ways.
Reference:
1. P. Sudarsanam, F. Winston, The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Trends Genet 16, 345 (2000).
|
| Cross-reference to other databases |
The family is only defined in PlantTFcat.
|