| Location: Details of STAT family |
| |
STAT |
| Family Type |
Transcription factor |
| Plant Specific |
No |
| Functional Domains |
DNA binding domain/protein-protein interacting domain/SH2 domain |
| Must-have InterProScan Domain Pattern |
IPR001217 or IPR012345 or IPR013799 or IPR013801 |
| Prohibited InterProScan Domain Pattern |
- |
| Description |
STATs are so named because they serve both Signal Transducers in the cytoplasm and Activators of Transcription in the nucleus. Each STAT molecule contains a Src-homology 2 (SH2) domain, that binds specifically to phosphotyrosine. The phosphorylated STATs form SH2-mediated dimers and are then translocated to the nucleus, where they bind to DNA and direct specific transcriptional initiation.
Reference:
1. X. Chen, U. Vinkemeier, Y. Zhao, D. Jeruzalmi, J. E. Darnell, Jr., J. Kuriyan, Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93, 827 (1998). |
| Cross-reference to other databases |
The family is the same family of STAT in PlantTFDB.
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