| Location: Details of PHD family |
| |
PHD |
| Family Type |
Chromatin regulator |
| Plant Specific |
No |
| Functional Domains |
Binding totrimethylated lysine Histone (H3K27me3) |
| Must-have InterProScan Domain Pattern |
IPR001965 or IPR011011 or IPR019787 or IPR019786 |
| Prohibited InterProScan Domain Pattern |
IPR004022 IPR001356 IPR003349 IPR004022 IPR001356 IPR003349 IPR001214 IPR009057 |
| Description |
Plants have to associate with Plant Homeo Domain (PHD)-finger proteins for efficient deposition of histone H3 trimethylated at lysine 27 (H3K27me3) and transcriptional repression. PHDs comprise a patch of phenylalanine and tyrosine residues called aromatic cage, which can occur in several domains and can interact with methylated lysine. Biochemical experiments demonstrated that the three proteins interact specifically with histone H3 methylated at lysine 4 via their PHDs.
Reference:
1. H. Li, S. Ilin, W. Wang, E. M. Duncan, J. Wysocka, C. D. Allis, D. J. Patel, Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442, 91 (2006)
2. K. Fortschegger, R. Shiekhattar, Plant homeodomain fingers form a helping hand for transcription. Epigenetics 6, 4 (2011) |
| Cross-reference to other databases |
The family is the same family of PHD in PlnTFDB.
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