Location: Details of Lambda-DB family |
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Lambda-DB |
Family Type |
Putative novel transcription factor |
Plant Specific |
No |
Functional Domains |
DNA binding domain |
Must-have InterProScan Domain Pattern |
IPR010982 or IPR000655 |
Prohibited InterProScan Domain Pattern |
- |
Description |
Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining lysogeny, where the phage replicates non-disruptively along with the host. If the host cell is threatened, then lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase, and a C-terminal dimerisation domain. This type of viral DNA binding domain is also presents some eukaryotic proteins.
Reference:
1. C. E. Bell, P. Frescura, A. Hochschild, M. Lewis, Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding. Cell 101, 801 (2000).
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Cross-reference to other databases |
The family is only defined in PlantTFcat.
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