Location: Details of LIM family |
|
LIM |
Family Type |
Transcription factor interactor and regulator |
Plant Specific |
No |
Functional Domains |
DNA binding domain |
Must-have InterProScan Domain Pattern |
IPR001781 |
Prohibited InterProScan Domain Pattern |
IPR001245 IPR001356 IPR009057 |
Description |
Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in eukaryotic transcription factors. Two cysteine and two histidine residues located in certain positions bind zinc to stabilize the structure. The number of zinc fingers in a single protein can vary over a wide range, and single zinc finger containing transcription factors are only present in plant kingdom. LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues.
Reference:
1. J. W. Michelsen, K. L. Schmeichel, M. C. Beckerle, D. R. Winge, The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A 90, 4404 (1993).
|
Cross-reference to other databases |
The family is the same family of LIM in PlnTFDB.
|