| Location: Details of KRAB-box family |
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KRAB-box |
| Family Type |
Transcription factor interactor and regulator |
| Plant Specific |
No |
| Functional Domains |
DNA binding domain |
| Must-have InterProScan Domain Pattern |
IPR001909 or IPR003655 |
| Prohibited InterProScan Domain Pattern |
IPR007087 |
| Description |
Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in eukaryotic transcription factors. Two cysteine and two histidine residues located in certain positions bind zinc to stabilize the structure. The number of zinc fingers in a single protein can vary over a wide range, and single zinc finger containing transcription factors are only present in plant kingdom. KRAB (Kr??ppel associated box)-containing proteins are characterized by the presence of a DNA-binding domain made up of between 4 and over 30 zinc-finger motifs and a KRAB domain. The KRAB domain, located near the amino terminus of the protein, consists of one or both of the KRAB A box and the KRAB B box.
Reference:
1. R. Urrutia, KRAB-containing zinc-finger repressor proteins. Genome Biol 4, 231 (2003).
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| Cross-reference to other databases |
The family is only defined in PlantTFcat.
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