Description |
Plant homeobox genes can be classified into 14 classes based on sequence differentiation and fusion with characteristic codomain sequences. Homeobox genes encode a typical DNA-binding domain of 60 amino acids, known as homeodomain. Typically, homeodomain folds into characteristic 3D structure containing three alpha-helices, of which the second and third form a helix-turn-helix motif.
The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins, including Myb proteins, GARP response regulators, human telomeric proteins (hTRF1) etc. This entry indicated a family which have a very homodomain like DNA binding domain.
Reference:
1. J Mol Evol 65, 137 (2007) 2. Mukherjee, K., Brocchieri, L., and Burglin, T.R. (2009). A comprehensive classification and evolutionary analysis of plant homeobox genes. Mol Biol Evol 26, 2775-2794.
2. K. Hosoda, A. Imamura, E. Katoh, T. Hatta, M. Tachiki, H. Yamada, T. Mizuno, T. Yamazaki, Molecular structure of the GARP family of plant Myb-related DNA binding motifs of the Arabidopsis response regulators. Plant Cell 14, 2015 (2002).
|