| Location: Details of HMG family |
| |
HMG |
| Family Type |
Chromatin remodeling & transcriptional activation |
| Plant Specific |
No |
| Functional Domains |
DNA binding domain |
| Must-have InterProScan Domain Pattern |
IPR009071 or IPR000116 or IPR000637 |
| Prohibited InterProScan Domain Pattern |
IPR006780 IPR001606 |
| Description |
The HMG-box is an approximately 75-amino acid residue protein domain that occurs in all eukaryotic organisms. The HMG-box domain mediates DNA binding primarily through its interaction to the minor groove of DNA. Structural studies have demonstrated that an L-shaped fold of the domain formed by three alpha helices is conserved.
The long arm of which is consists of helix III and the N-terminal extended strand, whereas the short arm of the L-shape is composed of helices I and II in an ~80°angle between the arms. HMG-box proteins induce DNA bending upon binding to linear DNA, they often act as architectural facilitators in the assembly of nucleoprotein complexes involved in transcription, recombination, or other DNA-dependent processes.
Reference:
1. M. Stros, D. Launholt, K. D. Grasser, The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins. Cell Mol Life Sci 64, 2590 (2007).
2. M. Antosch, S. A. Mortensen, K. D. Grasser, Plant proteins containing high mobility group box DNA-binding domains modulate different nuclear processes. Plant Physiol 159, 875 (2012).
|
| Cross-reference to other databases |
The family is the same family of HMG in PlnTFDB.
|