| Location: Details of FYR family |
| |
FYR |
| Family Type |
Chromatin remodeling & transcription regulator |
| Plant Specific |
No |
| Functional Domains |
Putative modified histone binding |
| Must-have InterProScan Domain Pattern |
IPR003888 or IPR003889 |
| Prohibited InterProScan Domain Pattern |
- |
| Description |
The FYRN and FYRC sequence motifs are phenylalanine/tyrosine-rich regions of around 50 and 100 amino acids, respectively, which are found in a variety of chromatin-associated proteins. FYRN and FYRC motifs are found in association with modules that create or recognize histone modifications in proteins from a wide range of eukaryotes, and it is likely that in these proteins they have a conserved role related to some aspect of chromatin biology. Based on the structure, a binding rather than a catalytic function seems more likely. The nature of a potential ligand, however, remains unclear, as the FYR domain does not resemble any of the protein modules known to recognize potential binding partners such as modified histones.
Reference:
1. M. M. Garcia-Alai, M. D. Allen, A. C. Joerger, M. Bycroft, The structure of the FYR domain of transforming growth factor beta regulator 1. Protein Sci 19, 1432 (2010). |
| Cross-reference to other databases |
The family is only defined in PlantTFcat.
|