| Location: Details of C2H2 family |
| |
C2H2 |
| Family Type |
Transcription factor |
| Plant Specific |
No |
| Functional Domains |
DNA/RNA binding domain and/Protein-Protein interacting domain |
| Must-have InterProScan Domain Pattern |
IPR007087 or IPR015880 or IPR013087 or IPR001841 |
| Prohibited InterProScan Domain Pattern |
IPR003349 IPR001965 IPR003349 IPR001965 IPR011011 IPR000306 IPR003888 IPR003889 IPR001356 |
| Description |
Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in eukaryotic transcription factors. Two cysteine and two histidine residues located in certain positions bind zinc to stabilize the structure. The number of zinc fingers in a single protein can vary over a wide range, and single zinc finger containing transcription factors are only present in plant kingdom. Besides DNA binding, zinc fingers can also provide protein-protein and RNA-protein interactions.
Reference:
1. S. V. Razin, V. V. Borunova, O. G. Maksimenko, O. L. Kantidze, Cys2His2 zinc finger protein family: classification, functions, and major members. Biochemistry (Mosc) 77, 217 (2012) |
| Cross-reference to other databases |
The family is the same family of C2H2 in PlantTFDB.
The family is the same family of C2H2 in PlnTFDB.
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