| Description |
Proteins containing bromodomains are small helical interaction modules, capable of binding to acetylated histone tails and have a role in recognizing acetylated chromatin. Histone tails acetylation is commonly an indicative mark of open chromatin architecture and transcriptional activation. Bromodomain is present in diverse eukaryotic species. They have a conserved 120 residue structural four helix motif. In Arabidopsis mutantion of bromodomain linked it with seed germinationas as well as for establishment of leaf shape.
Reference:
1. P. Filippakopoulos, S. Knapp, The bromodomain interaction module. FEBS Lett 586, 2692 (2012) 2. C. A. Airoldi, F. D. Rovere, G. Falasca, G. Marino, M. Kooiker, M. M. Altamura, S. Citterio, M. M. Kater, The Arabidopsis BET bromodomain factor GTE4 is involved in maintenance of the mitotic cell cycle during plant development. Plant Physiol 152, 1320 (2010) |