| Description |
In the RISC, the RNA-induced silencing complex along with DICER, two proteins, Arb1 and Arb2, both of which are required for histone H3 Lys9 (H3-K9) methylation, heterochromatin assembly and siRNA generation. Arb1 and Arb2 inhibit the release of the siRNA passenger strand from Ago1.
Reference:
1. Buker, S.M., Iida, T., Buhler, M., Villen, J., Gygi, S.P., Nakayama, J., and Moazed, D. (2007). Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Nat Struct Mol Biol 14, 200-207.
2. Kamminga, L.M., and Ketting, R.F. (2011). RNAi genes pave their own way. Genes Dev 25, 529-533. |