| Description |
The A20 proteins have a novel class of Cys2/Cys2 zinc finger domain. It may be present in tandem repeat or singularly. In animals it has been shown to modulate NF-kB signaling pathway. Recently it has been shown that 4-ZnF domain in A20 interact with K63-linked Ub. But weather this domain can bind to DNA directly is not determine yet and specific function of A20 Znf proteins in plant is also yet to be reported.
Reference:
1. P. C. Evans, E. R. Taylor, J. Coadwell, K. Heyninck, R. Beyaert, P. J. Kilshaw, Isolation and characterization of two novel A20-like proteins. Biochem J 357, 617 (2001)
2. I. Bosanac, I. E. Wertz, B. Pan, C. Yu, S. Kusam, C. Lam, L. Phu, Q. Phung, B. Maurer, D. Arnott, D. S. Kirkpatrick, V. M. Dixit, S. G. Hymowitz, Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling. Mol Cell 40, 548 (2010)
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